肠道菌群等代谢性因素对心血管疾病的影响。

肠道菌群-次生代谢-心血管轴调控心血管发育及疾病

宏基因组技术与人体健康，重点关注不同发育阶段肠道菌群特征及对其发育的影响，研究人体发育和肠道微生物组间的相互关系。

2011-01 - 2012-03，5822yh银河国际第一附属医院，助理研究员

2012-03 - 2014-12，美国Oklahoma大学，博士后

2015-01 - 2015-12，5822yh银河国际第一附属医院，副研究员

2016-01 - 2020-12，5822yh银河国际第一附属医院，医师

2021-01 -        ，5822yh银河国际第一附属医院，副主任医师

1.国家重点研究计划

不同发育阶段肠道菌群特征及对其发育的影响（NO：2019YFA0802300），1695万元，2019年12月-2024年11月。

2.国家自然科学基金

miRNA通过IKappaB调节炎性巨噬细胞对动脉粥样硬化发生发展的作用及机制（NO：81100209），23万元，2011年1月-2014年12月。

AMPK调节MKP1在尼古丁致动脉粥样硬化的机制研究（NO：81570406），57万元，2015年1月-2019年12月。

动脉粥样硬化与代谢性炎症（NO：81822005），130万元，2018年8月-2021年12月。

CRP促进eNOS聚集于内皮细胞膜而失活导致高血压的机制研究（NO：81970351），55万元，2019年8月-2023年12月。

3.陕西省自然科学基础研究计划

吸烟等危险因素致代谢性心血管疾病的机制及转化医学研究（NO：2017KJXX-79），10万元，2017年1月-2019年12月。

肠道菌通过胆汁酸-FXR-miRNA轴调控动脉粥样硬化的研究（NO：2020JM-383），3万元，2020年4月-2021年12月。

1.Lulu Sun, Cen Xie, Guang Wang, Yue Wu, Qing Wu, Xuemei Wang, Jia Liu, Yangyang Deng, Jialin Xia, Bo Chen, Songyang Zhang, Chuyu Yun, Guan Lian, Xiujuan Zhang, Heng Zhang, William H. Bisson, Jingmin Shi, Xiaoxia Gao, Pupu Ge, Cuihua Liu, Kristopher W. Krausz, Robert G. Nichols, Jingwei Cai, Bipin Rimal, Andrew D. Patterson, Xian Wang, Frank J. Gonzalez，Changtao Jiang. Gut microbiota and intestinal FXR mediate the clinical benefits of metformin. Nature Medicine, 2018 Dec;24(12):1919-1929. (期刊论文) (共同一作)

2.Yuanyuan Wei, Beidi Lan, Tao Zheng, Lin Yang, Xiaoxia Zhang, Lele Cheng, Gulinigaer Tuerhongjiang, Zuyi Yuan, Yue Wu. GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis. Nature Communications, 2023 Feb 18;14(1):929. (期刊论文) (末位通讯)

3.Yun Zhang, Song Zhang, Bolin Li, Yingchun Luo, Yongtai Gong, Xuexin Jin, Jiawei Zhang, Yun Zhou, Xiaozhen Zhuo, Zixi Wang, Xinbo Zhao, Xuejie Han, Yunlong Gao, Hui Yu, Desen Liang, Shiqi Zhao, Danghui Sun, Dingyu Wang, Wei Xu, Guangjin Qu, Wanlan Bo, Dan Li, Yue Wu, Yue Li. Gut microbiota dysbiosis promotes agerelated atrial fibrillation by lipopolysaccharide and glucose induced activation of NLRP3-inflammasome. Cardiovascular Research, 2022 Feb 21;118(3):785-797. (期刊论文) (共同通讯)

4.Lele Cheng, Tao Chen, Manyun Guo, Peining Liu, Xiangrui Qiao, Yuanyuan Wei, Jianqing She, Bolin Li, Wen Xi, Juan Zhou, Zuyi Yuan, Yue Wu，Junhui Liu. Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress. Clinical Science, 2021 Jul 30;135(14):1689-1706. (期刊论文) (共同通讯)

5.Lele Cheng, Liang Wang, Manyun Guo, Jinlong He, Yangyang Deng, Junhui Liu, Yuanyuan Wei, Chen Wang, Juan Zhou, Li Ma, Qing Song, Zuyi Yuan，Yue Wu. Clinically relevant high levels of human C-reactive protein induces endothelial dysfunction and hypertension by inhibiting the AMPK-eNOS axis. Clinical Science, 2020 Jul 17;134(13):1805-1819. (期刊论文) (末位通讯)

6.Yue Wu, Ping Song, Wencheng Zhang, Junhui Liu, Xiaoyan Dai, Zhaoyu Liu, Qiulun Lu, Changhan Ouyang, Zhonglin Xie, Zhengxing Zhao, Xiaozhen Zhuo, Benoit Viollet, Marc Foretz, Jiliang Wu, Zuyi Yuan，Ming-Hui Zou. Activation of AMPK α 2 in adipocytes is essential for nicotine-induced insulin resistance in vivo. Nature Medicine, 2015 Apr;21(4):373-82.(期刊论文) (第一作者)

7.Cen Xie, Tomoki Yagai, Yuhong Luo, Xianyi Liang, Tao Chen, Qiong Wang, Dongxue Sun, Jie Zhao, Sadeesh K Ramakrishnan, Lulu Sun, Chunmei Jiang, Xiang Xue, Yuan Tian, Kristopher W Krausz1, Andrew D Patterson, Yatrik M Shah, Yue Wu, Changtao Jiang，Frank J Gonzalez. Activation of intestinal hypoxia inducible factor 2 α during obesity contributes to hepatic steatosis. Nature Medicine, 2017 Nov;23(11):1298-1308. (期刊论文) (共同通讯)

8.Yuling Tian, Tao Chen, Yan Wu, Lin Yang, Lijun Wang, Xiaojuan Fan, Wei Zhang, Jiahao Feng, Hang Yu, Yanjie Yang, Juan Zhou, Zuyi Yuan，Yue Wu. Pioglitazone stabilizes atherosclerotic plaque by regulating the Th17/Treg balance in AMPK‑dependent mechanisms.  Cardiovascular Diabetology, 2017 Oct 30;16(1):140. (期刊论文) (末位通讯)

9.Jianqing She, Manyun Guo, Hongbing Li, Junhui Liu, Xiao Liang, Peining Liu, Bo Zhou, Simin Liu, Yangyang Deng, Bowen Lou, Chaofeng Sun, Zuyi Yuan，Yue Wu. Targeting amino acids metabolic profile to identify novel metabolic characteristics in atrial fibrillation. Clinical Science, 2018 Oct 5;132(19):2135-2146. (期刊论文) (末位通讯)

10.Lele Cheng, Zixuan Meng，Xiangrui Qiao，Qi Wang, Zhijie Jian, Pengcheng Fan, Xinxin Feng, Jian Yang, Zuyi Yuan, Bolin Li，Yue Wu. The Usefulness of C-Reactive Protein to Albumin Ratio in the Prediction of Adverse Cardiovascular Events in Coronary Chronic Total Occlusion Undergoing Percutaneous Coronary Intervention. Frontiers in Cardiovascular Medicine, 2021 Nov 12;8:731261. (期刊论文) (通讯作者)

11.Lele Cheng, Jie Rong, Xiaozhen Zhuo, Ke Gao, Zixuan Meng，Xing Wen, Shanshan Li, Pengcheng Fan，Xiang Hao, Zhijie Jian, Yue Wu, Bolin Li. Prognostic value of malnutrition using geriatric nutritional risk index in patients with coronary chronic total occlusion after percutaneous coronary intervention. Clinical Nutrition, 2021 Jun;40(6):4171-4179. (期刊论文) (共同通讯)

12.Bolin Li, Jie Rong, Bobo Wang, Ke Gao, Xing Wen, Hongbing Li, Lele Cheng, Yi-Ming Hua, Shanshan Li, Zhijie Jian, Yujing Zhang, Hui Huang, Youlong Pan, Yue Wu，Xiao-Zhen Zhuo. Cystatin C-Based Renal Function in Predicting the Long-Term Outcomes of Chronic Total Occlusion After Percutaneous Coronary Intervention. Frontiers in Cardiovascular Medicine, 2020 Nov 9;7:586181. (期刊论文) (共同通讯)

13.Shanshan Gao, Juan Zhou, Na Liu, Lijun Wang, Qiyue Gao, Yan Wu, Qiang Zhao, Peining Liu, Shun Wang, Yan Liu, Ning Guo, Yan Shen, Yue Wu, Zuyi Yuan. Curcumin induces M2 macrophage polarization by secretion IL-4 and/or IL-13. Journal of Molecular and Cellular Cardiology, 2015 Aug;85:131-9. (期刊论文) (共同通讯)

14. Xiao-Zhen Zhuo, Yue Wu, Ya-Juan Ni, Jun-Hui Liu, Min Gong, Xue-Hui Wang, Feng Wei, Ting-Zhong Wang, Zuyi Yuan, Ai-Qun Ma, Ping Song. Isoproterenol instigates cardiomyocyte apoptosis and heart failure via AMPK inactivation mediated endoplasmic reticulum stress. Apoptosis, 2013 Jul;18(7):800-10. (期刊论文) (共同一作)