生物医学超声 (Biomedical Ultrasound)

多模空化诊疗 (Multi-mode Cavitation Theranostics)

微纳米多功能材料 (Micro and Nano Functional Materials)

超声力生物学效应 (Ultrasound Mechanobiology)

药物运输与释放 (Drug Delivery)

2010-今，5822yh银河国际，讲师，副教授

2019．1-2020.1， 斯坦福大学，访问学者，（Prof. Ferrara）

2010，5822yh银河国际，生物医学工程，博士

2008，维也纳医科大学肿瘤研究所临床蛋白质组实验室，访问博士生（Prof. Christopher Gerner）

2002，5822yh银河国际，生物工程，学士

国家自然科学基金国际（地区）组织间合作项目，2020-2023，负责人

国家自然科学基金面上项目，2017-2020，负责人

国家自然科学基金青年项目，2013-2015，负责人

陕西省自然科学基金面上项目，2014-2016，负责人

教育部博士点基金项目，2012-2014，负责人

代表论著：

2. 万明习，冯怡，路舒宽. 计算生物医学超声学，科学出版社，北京，2017.

1. Wan MX, Feng Y, and G ter Haar (Eds.). Cavitation in Biomedicine: Principles and Techniques. Springer, 2015.

主要论文：

17.Tali Ilovitsh, Yi Feng, Josquin Foiret, Azadeh Kheirolomoom, Hua Zhang, Elizabeth S. Ingham, Asaf Ilovitsh, Spencer K. Tumbale, Brett Z. Fite, Bo Wu, Marina N. Raie, Nisi Zhang, Aris J. Kare, Michael Chavez, Lei S. Qi, Gadi Pelled, Dan Gazit, Ophir Vermesh, Idan Steinberg, Sanjiv S. Gambhir, and Katherine W. Ferrara. Low frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites. PNAS. 2020.

16. Feng Y, Qin D, Zhang J, Zhang L, Ayache Bouakaz, and Wan MX. Occlusion and rupture of ex vivo capillary bifurcation due to acoustic droplet vaporization. Applied Physics Letters, 2018, 112, 233701. (SCI)

15. Qin D, Zhang L, Chang N, Ni PY, Zong YJ, Ayache Bouakaz, Wan MX, Feng Y*. In situ obser-vation of single cell response to acoustic droplet vaporization: membrane deformation, permeabilization, and blebbing, Ultrasonics Sonochemistry 2018, 47, 141-150. (SCI)

14. Zhu HR, Qin D, Wu YS, Jing BW, Liu JJ, Hazlewood D, Zhang HM, Feng Y, Yang XM, Wan MX*, WU DC*. Laser-Activated Bioprobes with High Photothermal Conversion Efficiency for Sensitive Photoacoustic/Ultrasound Imaging and Photothermal Sensing. ACS Applied Materials & Interfaces, 2018, 10(35): 29251-29259.

13. Feng Y*, Dui Qin, Lei Zhang, Mingxi Wan. Photoacoustic cavitation of nanodroplets: high speed observation and acoustic signal analysis. Journal of Mechanics in medicine and Biology, 2017, 17(7) 1740033. (SCI)

12.Zhao L, Feng Y*, et al. Neuroprotective effect of low-intensity pulsed ultrasound against MPP+-induced neurotoxicity in PC12 cells: involvement of K2P channels and stretch-activated ion channels. Ultrasound in Medicine & Biology, 2017, 43(9): 1986-1999. (SCI)

11. Zhao L, Feng Y*, Hu H, et al. Low-Intensity Pulsed Ultrasound Enhances Nerve Growth Factor-induced Neurite Outgrowth through Mechanotransduction-Mediated Erk1/2–Creb–Trx-1 Signaling. Ultrasound in Medicine & Biology, 2016, 42(12): 2914-2925. (SCI)

10. Zhao L, Feng Y*, Shi AW, et al. Apoptosis Induced by Microbubble-Assisted Acoustic Cavitation in K562 Cells: The Predominant Role of the Cyclosporin A-Dependent Mitochondrial Permeability Transition Pore. Ultrasound in Medicine & Biology, 2015，41(10): 2755-2764. (SCI)

9.  Qin D, Feng Y*, Wan MX. Modeling photoacoustic cavitation nucleation and bubble dynamics with modified classical nucleation theory. The Journal of the Acoustical Society of America, 2015, 138: 1282-1289. (SCI)

8.  Feng Y, Qin D, Zhang J, et al. Acoustic signal characteristics of laser induced cavitation in DDFP droplet: Spectrum and time-frequency analysis. Bio-Medical Materials and Engineering, 2015, 26(S1): S2083-2089. (SCI)

7.  Feng Y, Wan MX. Potential Mechanism of Apoptosis Induced by Ultrasound in Human Hepatocarcinoma Cells via Comparative Proteomic Analysis. Bio-Medical Materials and Engineering, 2015, 26(S1): S423-427. (SCI)

6.  Feng Y, Tian ZM, Wan MX. Bio-effects of low intensity ultrasound in vitro: apoptosis, alteration of protein profile and potential molecular mechanism. Journal of Ultrasound in Medicine. 2010, 29: 963-974. (SCI)

5.  Feng Y, Tian ZM, Wan MX, et al. Low intensity ultrasound-induced apoptosis in human gastric carcinoma cells. World J Gastroenterol, 2008, 14(31): 4873-4879. (SCI)

4.  Feng Y, Tian ZM, Wan MX, et al. Protein profile of human hepatocarcinoma cell line SMMC-7721: Identification and functional analysis. World J Gastroenterol, 2007, 13(18): 2608-2614. (SCI)

3.  Xu SS, Zong YJ, Feng Y, et al. Dependence of pulsed focused ultrasound induced thrombolysis on duty cycle and cavitation bubble size distribution. Ultrasonics Sonochemistry, 2015, 22:160-166. (SCI)

2.  Lu MZ, Wang XD, Wan MX, Feng Y, et al. Image-Guided 256-Element Phased Array Focused Ultrasound Surgery: System and Multi-Focus Pattern Control. IEEE Engineering in Medicine and Biology Magazine, 2008, 27(5):84-9. (SCI)

1.  Lei DF, Feng Y, Jiang DZ. Characterization of polyphenol oxidase from plants. Progress in Natural Science, 2004, 14(7): 553-561. (SCI)

会议论文：

22. Feng Y, Qin D, Zhang L, et al. (2017). Optical and acoustic study on phase transition of nanodroplets: acoustic droplet vaporization versus photoacoustic cavitation. IEEE International Ultrasonics Symposium (IUS 2017), Washington DC, USA.

21. Feng Y, Qin D, Wan MX (2015). Photoacoustic cavitation for theranostics: mechanism, current progress and application. 9th International Symposium Cavitation (CAV2015), Lausanne, Switzerland.

20. Feng Y, Qin D, Zong YJ, et al. (2015) Optical and acoustic observation of photodisruption in two liquid perfluorocarbons induced by nanosecond laser. IEEE International Ultrasonics Symposium (IUS 2015), Taipei, Taiwan.

19. Zhao L, Feng Y*, Wan MX (2015). Effects of low-intensity pulsed ultrasound on nerve growth factor-induced neurite outgrowth and signaling in PC12 cells. IEEE International Ultrasonics Symposium (IUS 2015), Taipei, Taiwan.

18. Feng Y, Zhao L, Wan MX (2014). The alteration of protein profile of HepG2 cells during the apoptotic process induced by low intensity pulsed ultrasound. IEEE International Ultrasonics Symposium (IUS 2014), Chicago, USA.

17. Feng Y, Qin D, Ma CX, et al. (2014). Optic and acoustic detection of laser-induced optical breakdown in DDFP. IEEE International Ultrasonics Symposium (IUS 2014), Chicago, USA.

16. Feng Y, Wan MX (2014). Apoptosis induced by low-intensity ultrasound in vitro: alteration of protein profile and potential molecular mechanism. The 14th International Symposium on Therapeutic Ultrasound (ISTU2014), Las Vegas, USA.

15. Feng Y, Wan MX (2013). Low Intensity Ultrasound Induces Apoptosis via MPT Channel on Mitochondrial membrane: Target for Regulating Cancer Therapy or Not? The 13th International Symposium on Therapeutic Ultrasound (ISTU2013), Shanghai, China.

14. Feng Y, Wan MX. Early Changes Induced by Low Intensity Ultrasound in Human Hepatocarcinoma Cells. IFMBE Proceedings, 2009, 23(1-3): 1870-1873.

13. Feng Y, Wan MX. Bio-Effects of Ultrasound: Inhibitory Effects on Ultrasound Induced Apoptosis by Cyclosporin A and Fructose Supplementation[C]. 3rd International Conference on Bioinformatics and Biomedical Engineering (ICBEB 2009), Shanghai, China.

12. Feng Y, Tian ZM, Wan MX, et al. (2007) Analysis of the Potential Mechanism Related to the Apoptosis Induced by Ultrasound in Human Hepatocarcinoma Cells via Comparative Proteomic Methods. the International Congress on Ultrasonics (ICU2007), Vienna, Austria.

11. Zong YJ, Zou XR, Wang RR, Feng Y, et al. (2015) Ultrasound-enhanced extravasation of dual-modality multifunctional nanodroplets. IEEE International Ultrasonics Symposium (IUS 2015), Taipei, Taiwan.

10. Zong YJ, Wang RR, Zou XR, Zhang L, Feng Y, et al. (2015) Local cavitation induced vessel wall injury of artery and its potential application in animal model of atherosclerosis. IEEE International Ultrasonics Symposium (IUS 2015), Taipei, Taiwan.

9.  Gu JH, Wan MX, Wang SP, Feng Y (2007). Chirp-excitation pulse-inversion imaging of deeper microvascular. the International Congress on Ultrasonics (ICU2007), Vienna, Austria..

8.  Zhao L, Feng Y*, Shi AW, et al. (2015) Ultrasonic cavitation induced apoptosis: the key role of MPT pore. Joint Annual Conference of Chinese Biomedical Engineering (CBME 2015) Nan Jing, China(In Chinese)

7.  Qin D, Ma CX, Zhang J, Feng Y*, et al. (2015) Detection and Analysis of photoacoustic cavitation in phase-shift liquid. Joint Annual Conference of Chinese Biomedical Engineering (CBME 2015) Nan Jing, China. (In Chinese)

6.  Feng Y, Wan MX (2013). Proteomic study on low intensity focused ultrasound induced apoptosis in carcinoma cells. Annual Conference of Chinese Biomedical Ultrasound 2013. Chongqing, China. (Oral presentation) (In Chinese)

5.  Wang HJ, Feng Y*, Wan MX (2011). Study on Echo-PIV of hemodynamics in carotid artery based on CFD associated ultrasonic simulation. Joint Annual Conference of Chinese Biomedical Engineering (CBME 2011). (In Chinese)

4.  Feng Y, Wan MX (2009). Low intensity focused ultrasound induced apoptosis in carcinoma cells and its molecular mechanism. Joint Annual Conference of Chinese Biomedical Engineering (CBME 2009). (In Chinese)

3.  Wan MX, Feng Y, Zhang SY, et al. (2009) Transient phenomenon of ultrasonic microbubble cavitation and its molecular effects. Annual Conference of Chinese Biophysics Society. (In Chinese)

2.  Feng Y, Gao K, Tian ZM, et al. (2007) The effects of ultrasound on macromolecules and cells. Joint Annual Conference of Chinese Biomedical Engineering (CBME 2007). (In Chinese)

1.  Tian ZM, Feng Y, Zheng ZB, et al. (2005) The applications of proteomics in bioeffects of ultrasound. The Ultrasonic Medical EngineeringAcademic Conference 2005. (In Chinese)