免疫学（T细胞在胸腺中的发育）；

肿瘤的免疫治疗 。

学习经历：

1979.9-1984.7  西安医学院 医疗系 本科 医学学士

1995.4-1998.3   日本名古屋大学医学部研修生

1998.4-2002.4  日本名古屋大学医学系研究生科 博士研究生

2002.4-2004.3  日本社会科学促进会 外国人特别研究员 

               日本名古屋大学医学系研究生科 博士后研究员(合作导师：吉开泰信)

工作经历：

1984.8-1985.5  西安煤矿设计院医务所 医师

1985.5-1995.3  陕西省人民医院 外科医师

2004.4-2006.1  美国baylor医学院博士后研究员

2006.1- 2010.9   美国The University of Texas Medical Branch Dept of Micro & immune博士后研究员

2010.9 -2014.11    5822yh银河国际第二附属医院 血液科 

                   研究员   博士生导师

2014 11至今        5822yh银河国际第一附属医院 免疫肿瘤实验室

                   研究员   博士生导师

Publication: 

1.Yang Wei, Zhansheng Hu, Wen Gu, Gang Liu, Bingyin Shi, Enqi Liu, Tie Liu “CD117⁺CD44⁺ stem T cells develop in thymus and potently suppress T-cell proliferation by modulating the CTLA-4 pathway” Stem Cell Research & Therapy  Stem Cell Res Ther. 2017 Mar 9;8(1):56. doi: 10.1186/s13287-017-0495-4. （通讯作者 影响因子4.2)

2.Yahong Wang , Ting Chen, Haili Huang, Yun Jiang, Lawei Yang, Ziying Lin, Huijuan He, Tie Liu, Bin Wu, Jie Chen, David W. Kamp, Gang Liu “miR-363-3p inhibits tumor growth by targeting PCNA in lung adenocarcinoma”. Oncotarget 2017已接收(影响因子5.)

3.  Liu T, Wei Y, Liu G, Shi B, Giovanni S, Peterson JW, Chopra AK. A mutated cholera toxin without the ADP-ribosyltransferase activity induces cytokine production and inhibits apoptosis of splenocytes in mice possibly via toll-like receptor-4 signaling. Mol Immunol. 2016 Jul;75:21-7. (第一作者,通讯作者)

4. Gang Liu, Zongfang Li, Yang Wei, Yan Lin, Cengceng Yang, Tie Liu  Direct Detection of FoxP3 Expression in Thymic Double-Negative CD4^-CD8^- Cells by Flow Cytometry. scientific reports 2014. July.（通讯作者,影响因子5.2）

5.  Ziying Lin, Tie Liu, David W. Kamp, Yahong Wang, Huijuan He, Xu Zhou, Donghong Li, Lawei Yang, Bin Zhao, Gang Liu. AKT/mTOR and C-Jun N-terminal Kinase (JNK) Signaling Pathways Are Required for Chrysotile Asbestos-Induced Autophagy[J]. Free Radical Biology and Medicine, 2014 72:Pages 296–307. （并列第一作者,影响因子5.7）

6. PENG LI，TIE LIU, DAVID W. KAMP, ZIYING LIN, YAHONG WANG1, DONGHONG LI, LAWEI YANG1, HUIJUAN HE and GANG LIU.The JNK signaling pathway mediates chrysotile asbestos-induced alveolar epithelial cell apoptosis. Mol Med Rep. 2015 May;11(5):3626-34. doi: 10.3892/mmr.2014.3119. Epub 2014 Dec 19. (并列第一作者)

7. JinFeng Tang, ZhongHua Yu, Tie Liu, ZiYing Lin, Ya-Hong Wang, LaWei Yang, Hui-Juan He, Jun Cao, Hai-Li Huang, Gang Liu*.Five miRNAs as Novel Diagnostic Biomarker Candidates for Primary Nasopharyngeal Carcinoma.Asian Pac J Cancer Prev, 15 (18), 7575-7581.

8. Tie Liu, Bin Wu, Yahong Wang, Huijuan He, Ziying Lin, Jianxin Tan, Lawei Yang , David W Kamp, Xu Zhou, Jinfeng Tang, Haili Huang, Liangqing Zhang, Liu Bin, Gang Liu.PM2.5 induces autophagy via inhibition of thePI3K/Akt/mTOR-kinase signaling pathway in human bronchial epithelial cells.Mol Med Rep. 2015 Aug;12(2):1914-22. doi: 10.3892/mmr.2015.3577. Epub 2015 Mar 31 .

9.  Lawei Yang,Gang Liu,Ziying Lin,Yahong Wang,Huijuan He,Tie Liu,David W. Kamp.Pro-inflammatory response and oxidative stress induced by specific components in ambient particulate matter in human bronchial epithelial cells.Environ Toxicol.  2016 Aug;31(8):923-36. doi: 10.1002/tox.22102. 

10. Wang Y, Yang L, Li P, Huang H, Liu T, He H, Lin Z, Jiang Y, Ren N, Wu B, Kamp DW, Tan J, Liu G.Circulating microRNA signatures associated with childhood asthma Clin Lab. 2015;61(5-6):467-74. 

11. Haili huang, Yun Jiang, Yahong Wang , Ting Chen, Lawei Yang, Huijuan He, Ziying Lin ,Tie Liu ,  Teng Yang,David W Kamp , Bin Wu, Gang Liu . miR-5100 promotes tumor growth in lung cancer by targeting Rab6. Cancer Lett. 2015 Jun 28;362(1):15-24.

 12.Tie Liu ,Tetsuya Matsuguchi, Yetsuya matsuguchi, and Yasunobu Yoshikai:   Differences in interleukin-12 and -15 production by Dendritic cells at the early  Stage of listeria  monocytogenes infection between BALB/c and C57BL/6 mice. Cell. I.mmunnol.202,31-40.2000.

13.Tie Liu , Yetsuya matsuguchi, and Yasunobu Yoshikai: Differences in expression  of Toll-like Receptors and Their Reactivities in dendritic cells of C57BL/6 and   BALB/c mice . infection and immunity , Dec. 2002,p.6638-6645

14. Umemura ,Worawdh Wajjwalku ,Narin Upragarin TieLiu, Tetsuya Matuguchi,    Yukihiro Nishiyama,Garym.Wilson, and Yasunobu Yoshikai: Expression of mouse  mammary tumor Virus superantigen accelerates tumorigenicity of myeloma cells.  J.Virol.74 8226-8233.2000

15.Shinji Murosaki, Koutarou Mouryama,Yoshihiro Yamamoto,Hiroaki Kusaka,Tie Liu, and Yasunobu yoshikai. Immunopotentiating activity of  nigeroo- Ligosaccharides for the T helper1-Like immune response　mice .Biosci Biotechnol. Biochem, 63.373-378,1999.

16.Shinji Murosaki, Koutarou muroyama , Yoshihiro Yamamoto, TieLiu .　yasunobu  Yoshikai Nigerooligosaccharides augments natural killer activity of hepatic   mononuclear cells in mice Int.Immunopharm., 2000

17 Tie Liu,  Suzuki H , Hayakawa A, Nakashima, I Differences in chmokines    production   by Dendritic cells  between young and age mice. 31 th Proceedings of   the Japanese  Society  for   Immunology B2P 103  2003．

18.Tie Liu, Rolf Konig, Jian Sha, Chien-Te K. Tseng, G.R. Klimpel, and Ashok K. Chopra*  Immunological Responses of Salmonella enterica serovar Typhimurium Braun Lipoprotein and Lipid A mutants in a Mouse Model and their Potential Use as Live Attenuated Vaccines . Microbial pathogenesis:  2008 44(3):224-37. 

19. Tie Liu, Lynn Soong, Gang Liu, Rolf König, and Ashok K. Chopra The development of CD4⁺CD25⁺CD44⁺ regulatory T cells in mouse thymus 2009 biology direct Oct 23;4:40

20. Tie Liu and Ashok K. An Enteric Pathogen Salmonella enterica serovar   Typhimurium Suppresses Tumor Growth by Down Regulating CD44^high and CD4 T Regulatory (T_reg) Cell Expression in Mice: Critical Role of Lipopolysaccharide and  Braun Lipoprotein in Modulating Tumor Growth. Cancer Gene Ther. 2010 Feb;17(2):97-108.

21. Tie Liu,^, Stacy L. Agar, Jian Sha, Juan P. Olano, and Ashok K. Chopra   Deletion of Braun Lipoprotein Gene (lpp) Attenuates Yersinia pestis KIM/D27   Strain: Role of Lpp in Inducing NF-kB activation and host cell  Microb Pathog. 2010 Jan;48(1):42-52. 

22.  Tie Liu, Xia Huo，Gang Liu, and Ashok K. Chopra. “The majority of T cells, including Treg cells developed by CD4-CD8- T progenitor cells without the involvement of CD4+CD8+ stage in the thymus. Developmental &Comparative Immunology. 2013. Withdrown。

2010.9至今申请国家专利7项： 

1. 无纺布鼻罩            专利号：2011202387913.（第一发明人）

2. 无纺布隔离系统        专利号：201220158232.6（第一发明人）

3. 空气过滤门窗          专利号：201220524550x  （第一发明人）

4.小功率高效能节能层流病床 专利号：201210247526.0（第一发明人）

5.野外急救无纺布隔离罩式手术间 专利号2012103442495（第一发明人）

6. 一种提高骨髓移植成功率的体外细胞融合系统及方法  专利号： 201310362301.4 （第一发明人）